Regulatory RNAs : Basics, Methods and Applications. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Bibekanand Mallick, Zhumur Ghosh

出版情報:

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012

著者名:

• Mallick, Bibekanand.
• Ghosh, Zhumur.
• SpringerLink (Online service)

ISBN:

9783642225178 [3642225179]    

注記:

Renaissance of Regulatory RNAs -- Diversity, overlap and relationships in the small RNA landscape -- Fragments of small nucleolar RNAs as a new source for non-coding RNAs -- Small regulatory RNAs (sRNAs) – key players in prokaryotic metabolism, stress response and virulence -- The canonical RNA interference pathway in animals -- Generation of functional long non-coding RNA through transcription and natural selection -- MicroRNA regulation of neuronal differentiation and plasticity -- Long Non-coding RNA Function and Expression in Cancer -- Expression profiling of ncRNAs employing RNP libraries and custom LNA/DNA microarray analysis -- Targeted methods to improve small RNA profiles generated by deep sequencing -- Biocomputational identification of bacterial small RNAs and their target binding sites -- Identifying functional miRNA targets using over-expression and knockdown methods -- Identification of lncRNAs using computational and experimental approaches -- Experimental analyses of RNA-based regulations in B
Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addres

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