Functional Coherence of Molecular Networks in Bioinformatics. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Mehmet Koyutürk, Shankar Subramaniam, Ananth Grama

出版情報:

New York, NY : Springer New York : Imprint: Springer, 2012

著者名:

• Koyutürk, Mehmet.
• Subramaniam, Shankar.
• Grama, Ananth.
• SpringerLink (Online service)

ISBN:

9781461403203 [1461403200]    

注記:

Introduction to Network Biology -- Topological Characteristics of Molecular Networks -- Functional Annotation in Gene Networks -- Proteome Network Emulating Models -- Biological Network Alignment -- Pattern Mining across many Massive Biological Networks -- Molecular Networks and Complex Diseases -- Moving Towards Genome-Scale Kinetic Models: The Mass Action Stoichiometric Simulation Approach -- Index.
A fundamental problem in life sciences is the characterization of biological function. In medical sciences, understanding the bases of functional anomalies holds the key to effective diagnosis, treatment,  and prognosis; in genetics, functional annotation of genetic variability uncovers the complex relationship between genotype and phenotype; in evolutionary biology, functional differences between diverse organisms highlight the evolutionary mechanisms that underlie the complexity of biological systems. With the successful completion of the human genome project and recent technological advances in biological data collection, it has become possible to study biological function from a systems perspective. Today, Systems Biology is established as a fundamental interdisciplinary science, which focuses on systematic study of the complex mechanisms that orchestrate the cooperation between diverse molecules that compose life. In the study of biological systems, the complex interactions between biomolecules are often

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