Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants : New Vistas In Parkinson's Disease Therapy. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Lucyna Antkiewicz-Michaluk, Hans Rommelspacher

出版情報:

New York, NY : Springer US : Imprint: Springer, 2012

著者名:

• Antkiewicz-Michaluk, Lucyna.
• Rommelspacher, Hans.
• SpringerLink (Online service)

シリーズ名:

Current Topics in Neurotoxicity ; 1

ISBN:

9781461415428 [146141542X]    

注記:

Two faces of 1,2,3,4-tetrahydroisoquinoline mode of action in the mammalian brain: is it an endogenous neurotoxin or a neuromodulator? -- Isoquinolines as a neurotoxins: action and molecular mechanism -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline – a potent neuroprotecting agent -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline and addiction: experimental studies -- Beta-carbolines as neurotoxins -- Neuroprotective β-carbolines: occurrence, formation and biodegradation -- Beta-carbolines and neuroprotection: inhibition of monoamine oxidase -- Beta-carbolines increase the efficiency of the respiratory chain in mitochondria -- Antioxidant properties of β-carbolines -- Restoration of neuronal functions in damaged dopamine neurons: in vitro and in vivo studies -- Prospects for new treatment options in neurodegenerative diseases.
This book summarizes, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.  Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease. The specific topic, Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson's Disease Therapy, was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPT

ローカル注記:

学内専用E-BOOKS (local access only)