Biophysical Aspects of Transmembrane Signaling. 1st ed. 2005

種類:

電子ブック

責任表示:

edited by Sandor Damjanovich

出版情報:

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2005

著者名:

• Damjanovich, Sandor.
• SpringerLink (Online service)

シリーズ名:

Springer Series in Biophysics ; 8

ISBN:

9783540265115 [3540265112]    

注記:

The Impact of Environmental Signals on the Growth and Survival of Human T Cells -- Novel Single Cell Fluorescence Approaches in the Investigation of Signaling at the Cellular Level -- Non-Random Patterns of Membrane Proteins and Their Roles in Transmembrane Signaling -- Transmembrane Signals Mediated by IL-2 and IL-15 Control the Life and Death of Lymphocytes -- Single-Molecule Imaging of Diffusion, Recruitment, and Activation of Signaling Molecules in Living Cells -- Chemokine Signaling: The Functional Importance of Stabilizing Receptor Conformations -- Signaling and Reverse Signaling in the Tumor Necrosis Factor/TNF Receptor System -- Regulation of Immunoreceptor Activities: The Paradigm of the Type I Fc? Receptor -- Histamine Receptors and Signaling -- Signal Transduction by Ion Channels in Lymphocytes.
Transmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the side of a high number of complex biochemical events and an equally high number of physical changes at molecular and cellular levels at the same time. Both types of researchers were convinced that their findings are the most decisive, having higher importance than the findings of the other scientist population. Both casts were wrong. Life, even at cellular level, has a number of interacting physical and biochemical mechanisms, which finally build up the creation of an "excited" cell that will respond to particular signals from the outer or inner world. This book handles both aspects of the signalling events, and in some cases tries to unify our concepts and help understand the signals that govern the life and death of our cells. Not only the understanding, bu

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