Non-Protein Coding RNAs. 1st ed. 2009

種類:

電子ブック

責任表示:

edited by Nils Walter, Sarah A. Woodson, Robert T. Batey

出版情報:

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2009

著者名:

• Walter, Nils.
• Woodson, Sarah A.
• Batey, Robert T.
• SpringerLink (Online service)

シリーズ名:

Springer Series in Biophysics ; 13

ISBN:

9783540708407 [3540708405]    

注記:

RNA 3D Structural Motifs: Definition, Identification, Annotation, and Database Searching -- Theory of RNA Folding: From Hairpins to Ribozymes -- Thermodynamics and Kinetics of RNA Unfolding and Refolding -- Ribozyme Catalysis of Phosphodiester Bond Isomerization: The Hammerhead RNA and Its Relatives -- The Small Ribozymes: Common and Diverse Features Observed Through the FRET Lens -- Structure and Mechanism of the glmS Ribozyme -- Group I Ribozymes as a Paradigm for RNA Folding and Evolution -- Group II Introns and Their Protein Collaborators -- Understanding the Role of Metal Ions in RNA Folding and Function: Lessons from RNase P, a Ribonucleoprotein Enzyme -- Beyond Crystallography: Investigating the Conformational Dynamics of the Purine Riboswitch -- Ligand Binding and Conformational Changes in the Purine-Binding Riboswitch Aptamer Domains -- The RNA–Protein Complexes of E. coli Hfq: Form and Function -- Assembly of the Human Signal Recognition Particle -- Forms and Functions of Telomerase RNA -- Ribosomal
This book assembles chapters from experts in the Biophysics of RNA to provide a broadly accessible snapshot of the current status of this rapidly expanding field. The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, highlighting just one example of a large number of non-protein coding RNAs. Because non-protein coding RNAs outnumber protein coding genes in mammals and other higher eukaryotes, it is now thought that the complexity of organisms is correlated with the fraction of their genome that encodes non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic transposons, higher-level organization of eukaryotic chromosomes, and gene expression itself are found to largely be directed by non-protein coding RNAs. The biophysical study of these RNAs employs X-ray crystallography, NMR, ensemble and single molecule fluorescence spectroscopy, optical tweezers, cryo-electron microscopy, and ot

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