Cellular Signaling in Health and Disease. 1st ed. 2009

種類:

電子ブック

責任表示:

by Martin Beckerman

出版情報:

New York, NY : Springer New York : Imprint: Springer, 2009

著者名:

• Beckerman, Martin.
• SpringerLink (Online service)

シリーズ名:

Biological and Medical Physics, Biomedical Engineering ;

ISBN:

9780387981734 [038798173X]    

注記:

Metabolic Syndromes -- Energy Balance -- Insulin Signaling and Type 2 Diabetes -- Metabolic Program Execution and Switching -- Cholesterol -- Atherosclerosis -- Chronic Inflammation -- Redox Signaling -- Cancer -- The Cell Cycle -- Cell Cycle Checkpoints and DNA Damage Repair -- Apoptosis and Senescence -- Epigenetics -- Tumor Growth -- Tumor Metabolism -- Metastasis -- Neurodegeneration -- Protein Folding, Misfolding, and Aggregation -- Alzheimer’s Disease -- Chaperones, Endoplasmic Reticulum Stress, and the Unfolded Protein Response -- Parkinson’s Disease -- Huntington’s Disease and Amyotrophic Lateral Sclerosis.
In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling

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