Coarse-Grained Modelling of DNA and DNA Self-Assembly. 1st ed. 2012
- 種類:
- 電子ブック
- 責任表示:
- by Thomas E. Ouldridge
- 出版情報:
- Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012
- 著者名:
- シリーズ名:
- Springer Theses, Recognizing Outstanding Ph.D. Research ;
- ISBN:
- 9783642305177 [3642305172]
- 注記:
- A Novel DNA Model -- Methods -- Finite Size Effects -- Structural and Mechanical Properties of Model DNA -- Thermodynamic Properties of Model DNA -- Modelling DNA Tweezers -- Modelling a DNA Walker.
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology. - ローカル注記:
- 岐阜大学構成員専用E-BOOKS (Gifu University members only)
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