Molecular and Cellular Signaling. 1st ed. 2005

種類:

電子ブック

責任表示:

by Martin Beckerman

出版情報:

New York, NY : Springer New York : Imprint: Springer, 2005

著者名:

• Beckerman, Martin.
• SpringerLink (Online service)

シリーズ名:

Biological and Medical Physics, Biomedical Engineering ;

ISBN:

9780387260150 [0387260153]    

注記:

The Control Layer -- Exploring Protein Structure and Function -- Macromolecular Forces -- Protein Folding and Binding -- Stress and Pheromone Responses in Yeast -- Two-Component Signaling Systems -- Organization of Signal Complexes by Lipids, Calcium, and Cyclic AMP -- Signaling by Cells of the Immune System -- Cell Adhesion and Motility -- Signaling in the Endocrine System -- Signaling in the Endocrine and Nervous Systems Through GPCRs -- Cell Fate and Polarity -- Cancer -- Apoptosis -- Gene Regulation in Eukaryotes -- Cell Regulation in Bacteria -- Regulation by Viruses -- Ion Channels -- Neural Rhythms -- Learning and Memory.
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases

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