Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents. 1st ed. 2018
- 種類:
- 電子ブック
- 責任表示:
- by Akihiro Hirakawa, Hiroyuki Sato, Takashi Daimon, Shigeyuki Matsui
- 出版情報:
- Tokyo : Springer Japan : Imprint: Springer, 2018
- 著者名:
- シリーズ名:
- JSS Research Series in Statistics ;
- ISBN:
- 9784431555735 [4431555730]
- 注記:
- 1. Introduction -- 2. Phase I Trials for Drug Development in Oncology -- 3. A Summary of Dose -- Finding Methods in Standard Phase I Trials -- 4. Phase I Trials for Combination of Two Agents -- 5. Phase I Trials for Joint Assessment of Both Efficacy and Toxicity -- 6. Additional Topics on Adaptive Dose -- Finding Methods.
This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of adaptive dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with advanced materials for designing, conducting, monitoring, and analyzing adaptive dose-finding trials. The topics in the book are mainly related to cancer clinical trials, but many of those topics are potentially applicable or can be extended to trials for other diseases. The focus is mainly on model-based dose-finding methods for two kinds of phase I trials. One is clinical trials with combinations of two - ローカル注記:
- 学内専用E-BOOKS (local access only)
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