Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics : Homogeneous and Heterogeneous Approaches. 2nd ed. 2016

種類:

電子ブック

責任表示:

by Panos Macheras, Athanassios Iliadis

出版情報:

Cham : Springer International Publishing : Imprint: Springer, 2016

著者名:

• Macheras, Panos.
• Iliadis, Athanassios.
• SpringerLink (Online service)

シリーズ名:

Interdisciplinary Applied Mathematics ; 30

ISBN:

9783319275987 [3319275984]    

注記:

Part I: Basic Concepts -- The Geometry of Nature -- Diffusion and Kinetics -- Nonlinear Dynamics -- Part II: Modeling in Biopharmaceutics -- Drug Release -- Drug Dissolution -- Oral Drug Absorption -- Part III: Modeling in Pharmacokinetics -- Empirical Models -- Deterministic Compartmental Models -- Fractional Pharmacokinetics -- Modeling and Simulation in Bioequivalence -- Stochastic Compartmental Models -- Part IV: Modeling in Pharmacodynamics -- Classical Pharmacodynamics -- Nonclassical Pharmacodynamics -- Appendices.
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interf

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