Heteroaromatic Lipoxin A4 Analogues : Synthesis and Biological Evaluation. 1st ed. 2012

種類:

電子ブック

責任表示:

by Colm Duffy

出版情報:

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012

著者名:

• Duffy, Colm.
• SpringerLink (Online service)

シリーズ名:

Springer Theses, Recognizing Outstanding Ph.D. Research ;

ISBN:

9783642246326 [364224632X]    

注記:

Introduction -- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues -- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues -- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues -- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines -- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

ローカル注記:

学内専用E-BOOKS (local access only)