Advances in Mitochondrial Medicine. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Roberto Scatena, Patrizia Bottoni, Bruno Giardina

出版情報:

Dordrecht : Springer Netherlands : Imprint: Springer, 2012

著者名:

• Scatena, Roberto.
• Bottoni, Patrizia.
• Giardina, Bruno.
• SpringerLink (Online service)

シリーズ名:

Advances in Experimental Medicine and Biology ; 942

ISBN:

9789400728691 [9400728697]    

注記:

Section I – Physiology and structure of Mitochondria -- 1.               The oxidative phosphorylation system in mammalian mitochondria -- 2. Physiology and pathophysiology of mitochondrial DNA -- 3. Mitochondrial calcium as a key regulator of mitochondrial activities -- 4. Mitochondria and Nitric Oxide: Chemistry and Pathophysiology -- 5. Mitochondria and reactive oxygen species - which role in physiology and pathophysiology? -- 6. Uncoupling proteins: molecular, functional, regulatory, physiological and pathological aspects -- 7. The mitochondrial pathways of apoptosis -- Section II – Mitochondria and disease -- 8. Inherited mitochondrial disorders -- 9. Mitochondria and metabolism diseases -- 10. Mitochondria and diabetes. An intriguing pathogenetic role -- 11. Mitochondria and heart diseases -- 12. Mitochondria in neurodegeneration -- 13. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation -- Section III – Mitochondria and Aging -- 14.Mitochondria and aging -
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In t

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