Endoplasmic Reticulum Stress in Health and Disease. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Patrizia Agostinis, Samali Afshin

出版情報:

Dordrecht : Springer Netherlands : Imprint: Springer, 2012

著者名:

• Agostinis, Patrizia.
• Afshin, Samali.
• SpringerLink (Online service)

ISBN:

9789400743519 [9400743513]    

注記:

The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome.  This book primarily focuses on the pathophysiology of ER stress.  It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protei

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