Influenza Virus Sialidase - A Drug Discovery Target. 1st ed. 2012
- 種類:
- 電子ブック
- 責任表示:
- edited by Mark Itzstein
- 出版情報:
- Basel : Springer Basel : Imprint: Springer, 2012
- 著者名:
- シリーズ名:
- Milestones in Drug Therapy ;
- ISBN:
- 9783764389277 [3764389273]
- 注記:
- Influenza Virus Virology -- Investigating the interaction between influenza and sialic acid – making and breaking the link -- Enzymology of Influenza Virus Sialidase -- Influenza Virus Sialidase and Structure-Based Drug Design -- The Development of Carbohydrate-based Influenza Virus Sialidase Inhibitors -- The Development of Non-carbohydrate-based Influenza Virus Sialidase Inhibitors -- Clinical Experience with Influenza Virus Sialidase Inhibitors -- Resistance Development to Influenza Virus Sialidase Inhibitors.
Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topi - ローカル注記:
- 岐阜大学構成員専用E-BOOKS (Gifu University members only)
類似資料:
Springer New York : Imprint: Springer |
Springer-Verlag Berlin Heidelberg |
Springer Basel : Imprint: Springer |
8
電子ブック
Clinical Use of Anti-infective Agents : A Guide on How to Prescribe Drugs Used to Treat Infections
Springer New York : Imprint: Springer |
Springer New York : Imprint: Springer |
Springer Netherlands : Imprint: Springer |
Springer New York : Imprint: Springer |
Springer Basel : Imprint: Springer |
5
電子ブック
Multifunctional Nanoparticles for Drug Delivery Applications : Imaging, Targeting, and Delivery
Springer New York : Imprint: Springer |
Springer Science+Business Media, LLC |
Springer-Verlag Berlin Heidelberg |
Springer Netherlands : Imprint: Springer |