Serotonin and Anxiety : Neuroanatomical, Pharmacological, and Functional Aspects. 1st ed. 2012

種類:

電子ブック

責任表示:

by Caio Maximino

出版情報:

New York, NY : Springer New York : Imprint: Springer, 2012

著者名:

• Maximino, Caio.
• SpringerLink (Online service)

シリーズ名:

SpringerBriefs in Neuroscience ;

ISBN:

9781461440482 [1461440483]    

注記:

Introduction and scope of the review -- Anxiety and risk assessment -- Fear/panic and the fight/flight/freeze system -- “Coping” styles, stress reactivity, and the active-passive continuum -- Serotonin in the nervous system of vertebrates -- Synthesis and metabolism of serotonin -- Transport of serotonin: SERT and uptake -- Serotonin receptors -- 5-HT1A receptors -- 5-HT1B receptors -- 5-HT2C receptors -- Nodal structures in anxiety-like and panic-like responses -- Nodal structures regulating anxiety: The behavioral inhibition system -- “Limbic” portions of the medial prefrontal cortex -- The extended amygdala -- The ventral hippocampus -- The lateral habenula -- Nodal structures regulating panic: The cerebral aversive system -- The central amygdala -- The medial hypothalamic defense system -- The mesopontine rostromedial tegmental nucleus -- The periaqueductal gray area -- Locus coeruleus -- The dual role hypothesis -- Destruction or blockade of DRN neurons is anxiolytic and panicogenic -- The defensive cont
Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin – the neurotransmitter which has probably most captured the imagination of laymen and academics alike – is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological organization of the serotonergic system. In this book, the author summarizes the latest findings regarding the role of serotonin in modulating the activity of brain regions which organize behavioral patterns associated with fear, anxiety and stress. The emergent picture is one of far greater complexity than previously thought: while the serotonergic innervation of those brain regions arises from the same structure – the dorsal raphe

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