Notch Regulation of the Immune System. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Freddy Radtke

出版情報:

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012

著者名:

• Radtke, Freddy.
• SpringerLink (Online service)

シリーズ名:

Current Topics in Microbiology and Immunology ; 360

ISBN:

9783642242946 [3642242944]    

注記:

Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This volume of Current Topics in Microbiology and Immunology covers divers topics of Notch function within the immune system.  The review series starts with an overview on the role of Notch function for the generation, and specification of hematopoietic stem cells during mouse development and adulthood. Chapters follow describing molecular players and specific functions of Notch during T cell lineage commitment and maturation in both mouse and human. Once T cell development is accomplished and T cells have been positively and negatively selected, they migrate from the thymus to the periphery. There they regulate host defense to pathogens as well a

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