Phosphoinositides I: Enzymes of Synthesis and Degradation. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Tamas Balla, Matthias Wymann, John D. York

出版情報:

Dordrecht : Springer Netherlands : Imprint: Springer, 2012

著者名:

• Balla, Tamas.
• Wymann, Matthias.
• York, John D.
• SpringerLink (Online service)

シリーズ名:

Subcellular Biochemistry ; 58

ISBN:

9789400730120 [9400730128]    

注記:

1. The Phosphatidylinositol 4-kinases: Don’t Call it a Comeback -- 2. PIP kinases from the cell membrane to the nucleus -- 3. The Phospholipase C Isozymes and Their Regulation.- 4. Phosphoinositide 3-Kinases – A Historical Perspective -- 5. PI 3-kinases – drug targets in inflammation and cancer -- 6. Phosphoinositide 3-kinases in health and disease -- 7. Phosphoinositide phosphatases: just as important as the kinases -- 8. The PTEN and myobubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phos

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