Glioma : Immunotherapeutic Approaches. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by ryuya yamanaka

出版情報:

New York, NY : Springer New York : Imprint: Springer, 2012

著者名:

• yamanaka, ryuya.
• SpringerLink (Online service)

シリーズ名:

Advances in Experimental Medicine and Biology ; 746

ISBN:

9781461431466 [1461431468]    

注記:

Molecular Biology of Glioma -- Recent Surgical Management of Gliomas -- Recent Medical Management of Glioblastoma -- Basic Concepts in Glioma Immunology -- Mechanisms of Immune Evasion by Gliomas -- Glioma Antigen -- Cytokine Therapy -- Immunotherapeutic Approach with Oligodeoxynucleotides Containing CpG Motifs (CpG‑ODN) in Malignant Glioma -- Adoptive Cell Transfer Therapy for Malignant Gliomas -- Monoclonal Antibody Therapy for Malignant Glioma -- Animal Models for Vaccine Therapy -- Immunogene Therapy -- Peptide Vaccine -- Active Immunotherapy: Oncolytic Virus Therapy Using HSV‑ 1 -- Dendritic Cell Vaccines -- Antigen‑Receptor Gene‑Modified T Cells for Treatment of Glioma -- Glioma Stem Cell Research for the Development of Immunotherapy.
Treatment of glioma is currently one of the most challenging problems in oncology, as well as in neurosurgery. Despite major advances in our understanding of the pathomechanism, diagnosis by imaging and the availability of powerful therapeutic tools, the life expectancy of patients with glioblastoma has only been slightly prolonged and a cure remains elusive. None of the currently available surgical tools, including operative microscopes, lasers and image-guided surgery, can enable the detection and removal of all of the tumor tissue. In recent years, however, the landscape has been changing immeasurably, and molecular studies over the past two decades have identified a variety of genetic aberrations that are specifically associated with individual types of gliomas. In addition, certain molecular abnormalities have been linked to therapy responses, thereby establishing clinical biomarkers and molecular targets, and the use of novel agents is being investigated. These agents have been specifically engineered t

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