Sex and Gender Differences in Pharmacology. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Vera Regitz-Zagrosek

出版情報:

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012

著者名:

• Regitz-Zagrosek, Vera.
• SpringerLink (Online service)

シリーズ名:

Handbook of Experimental Pharmacology ; 214

ISBN:

9783642307263 [3642307264]    

注記:

From the contents -- Preface -- Part 1: Sex differences in mechanisms of disease -- Part 2: Sex differences in pharmaco­kinetics, in drug development and use -- Part 3: Sex differences in different therapeutic areas.
This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

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