Mortalin Biology: Life, Stress and Death. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Sunil C. Kaul, Renu Wadhwa

出版情報:

Dordrecht : Springer Netherlands : Imprint: Springer, 2012

著者名:

• Kaul, Sunil C.
• Wadhwa, Renu.
• SpringerLink (Online service)

ISBN:

9789400730274 [9400730276]    

注記:

Contributors -- Foreword -- Preface -- Section 1: Structure and Function of Mortalin.-  1. Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer.-  2. Mortalin’s Machinery.-  3. The Role of Mortalin in Iron Homeostasis .-  4. Functional Characteristics of Mortalin.- Section 2:  Mortalin in Evolution2 Deocaris.-  5.  Mortalin and Drosophila DmHsp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis .-  6. Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes  .-  7. Mortalin and Stem Cells: A Study from Planarians.-  Section 3: Mortalin in Health and Disease.-  8. Mortalin in Cell Protection from Immune Attack .-  9. Mortalin in Neurological Diseases.-  10. Loss of Mortalin Function in Parkinson’s Disease – Supporting the Mitochondrial Pathway of Neurodegeneration.-  11. Hsp75/mortalin and Protection from Ischemic Brain Injury -- 12. Catecholamin
The phrase “Life, stress and death” connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume “Mortalin Biology: Life, Stress and Death” is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it describes mortalin playing essential role in life, stress response and death either from cancer, when it becomes hyperactive or from neuro-degeneration, when it becomes hypoactive. The book provides up-to-date knowledge on mortalin with respect to its discovery, structure, evolutionary conservation, function and signal transduction in different organisms in a simple, but most comprehensive way, that besides offering an enjoyable and in-depth reading, prompts the reader to ask further questions to explore this protein with new ideas, approaches and experiments. Twenty-one chapters by the world leaders on the specific areas

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