Mucosal Vaccines : Modern Concepts, Strategies, and Challenges. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Pamela A. Kozlowski

出版情報:

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012

著者名:

• Kozlowski, Pamela A.
• SpringerLink (Online service)

シリーズ名:

Current Topics in Microbiology and Immunology ; 354

ISBN:

9783642236938 [3642236936]    

注記:

Most human pathogens utilize mucosal surfaces to access the host. This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous

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