Store-operated Ca2+ entry (SOCE) pathways : Emerging signaling concepts in human (patho)physiology. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Klaus Groschner, Wolfgang Graier, Christoph Romanin

出版情報:

Vienna : Springer Vienna : Imprint: Springer, 2012

著者名:

• Groschner, Klaus.
• Graier, Wolfgang.
• Romanin, Christoph.
• SpringerLink (Online service)

ISBN:

9783709109625 [3709109620]    

注記:

Preface (C. Romanin, W. F. Graier, K. Groschner) -- SECTION 1: SOCE – Fundamental mechanistic concepts -- Introduction (J. W. Putney) -- 1.1 The STIM-Orai pathway -- Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura) -- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan) -- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin) -- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem) -- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu) -- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca) -- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: E
Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.

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