A Structural Perspective on Respiratory Complex I : Structure and Function of NADH:ubiquinone oxidoreductase. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Leonid Sazanov

出版情報:

Dordrecht : Springer Netherlands : Imprint: Springer, 2012

著者名:

• Sazanov, Leonid.
• SpringerLink (Online service)

ISBN:

9789400741386 [9400741383]    

注記:

Complex I (NADH:ubiquinone oxidoreductase) is the first and largest enzyme of the respiratory chain in mitochondria and plays a central role in cellular energy production. Complex I dysfunction has been implicated in many human neurodegenerative diseases, including Parkinson’s. Mutations in complex I subunits are among the most common human genetic disorders known. Until recently, in the absence of structural information, complex I was the least understood enzyme of the respiratory chain. The mechanism by which it couples electron transfer between NADH and quinone to the translocation of protons across the membrane was a complete enigma. Recent years have been marked by spectacular progress in the elucidation of complex I’s structure, finally allowing the interpretation of a wealth of data accumulated in about 50 years since the discovery of the enzyme. Understanding of the mechanism of this large molecular machine, involving long-range conformational changes, is beginning to emerge. This book is the first de

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