Anticarbohydrate Antibodies : From Molecular Basis to Clinical Application. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Paul Kosma, Sven Müller-Loennies

出版情報:

Vienna : Springer Vienna : Imprint: Springer, 2012

著者名:

• Kosma, Paul.
• Müller-Loennies, Sven.
• SpringerLink (Online service)

ISBN:

9783709108703 [3709108705]    

注記:

1 Antibodies and Synthetic Vaccines against Shigella O-Antigens -- 2 Synthetic Oligosaccharide Bacterial Antigens to Produce Monoclonal Antibodies for Diagnosis and Treatment of Disease Using Bacillus anthracis as a Case Study -- 3 The Role of Sialic acid in the Formation of Protective Conformational Bacterial Polysaccharide Epitopes -- 4 Antibody Recognition of Chlamydia LPS: Structural Insights of Inherited Immune Responses.-  5 Designing a Candida albicans Conjugate Vaccine by Reverse Engineering Protective Monoclonal Antibodies.- 6 Binding Properties, Structural Significances and Production of the Neutralizing Anti-HIV Antibody 2G12.- 7 Immune Recognition of Parasite Glycans -- 8 Human IgE Antibodies against Cross-reactive Carbohydrate Determinants.-  9 Structural Glycobiology of Antibody Recognition in Xenotransplantation and Cancer Immunotherapy -- 10 Carbohydrate Mimetic Peptide Vaccines -- 11 Antitumor Vaccines Based on Mucin Glycopeptides --  12 Glycan Microarray Analysis of Tumor Specific Antibodies
Anticarbohydrate Antibodies – from molecular basis to clinical application compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecul

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