Aging Research in Yeast. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Michael Breitenbach, S. Michal Jazwinski, Peter Laun

出版情報:

Dordrecht : Springer Netherlands : Imprint: Springer, 2012

著者名:

• Breitenbach, Michael.
• Jazwinski, S. Michal.
• Laun, Peter.
• SpringerLink (Online service)

シリーズ名:

Subcellular Biochemistry ; 57

ISBN:

9789400725614 [9400725612]    

注記:

1. Preface and Introduction to Aging research in Yeast -- 2.Oxidative stresses and ageing -- 3.The role of Mitochondria in the aging processes of yeast -- 4.The Retrograde Response and Other Pathways of Interorganelle Communication in Yeast Replicative Aging -- 5. Chronological Aging in Saccharomyces cerevisiae -- 6. Still waters run deep: Aging and the survival of quiescent and non-quiescent cells in yeast stationary-phase cultures -- 7. Maximising the yeast chronological lifespan -- 8.Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae -- 9. DNA damage and DNA replication stress in yeast models of aging -- 10.Yeast aging and apoptosis.-11. Cellular homeostasis in fungi: Impact on the aging process -- 12.Genome-wide analysis of yeast aging -- 13. Genetic Approaches to Aging in Budding and Fission Yeasts: New Connections and New Opportunities -- 14. Evolution of asymmetric damage segregation: a modelling approach.-15. Cellular ageing and the actin cytoskeleton.
This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of

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