Studies on Retinal and Choroidal Disorders. 1st ed. 2012

種類:

電子ブック

責任表示:

edited by Robert D. Stratton, William W. Hauswirth, Thomas W. Gardner

出版情報:

Totowa, NJ : Humana Press : Imprint: Humana, 2012

著者名:

• Stratton, Robert D.
• Hauswirth, William W.
• Gardner, Thomas W.
• SpringerLink (Online service)

シリーズ名:

Oxidative Stress in Applied Basic Research and Clinical Practice ;

ISBN:

9781617796067 [1617796069]    

注記:

Review of Emerging Treatments for Age-Related Macular Degeneration -- Complement Pathways and Oxidative Stress in Models of Age-Related Macular Degeneration -- Oxidative Modifications As Triggers of AMD Pathology -- Role of Malondialdehyde in the Age-Related Macular Degeneration -- Bisretinoid Lipofuscin in the Retinal Pigment Epithelium: Oxidative Processes and Disease Implications -- Age-related Changes in RPE Lipofuscin Leads to Hydrophobic Polymers -- Docosahexaenoic Acid Signalolipidomics in the Homeostatic Modulation of Photoreceptor/Retinal Pigment Epithelial Cell Integrity During Oxidative Stress -- Role of Photoreceptor Retinol Dehydrogenases in Detoxification of Lipid Oxidation Products -- Glutathione Metabolism and its Contribution to Anti-Apoptotic Properties of α-Crystallins in the Retina -- The Role of Mitochondrial Oxidative Stress in Retinal Dysfunction -- Endoplasmic Reticulum Response to Oxidative Stress in RPE -- The Role of Iron in Retinal Diseases -- Mechanisms of Pathological VEGF Produc
Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid.  Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of  oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina.  It examines the anti-apoptotic activity of α-crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina.   A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of

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