Ibuprofen: Pharmacology, Therapeutics and Side Effects. 1st ed. 2012

種類:

電子ブック

責任表示:

by K. D. Rainsford

出版情報:

Basel : Springer Basel : Imprint: Springer, 2012

著者名:

• Rainsford, K. D.
• SpringerLink (Online service)

ISBN:

9783034804967 [3034804962]    

注記:

Introduction -- Biodisposition in relation to actions -- Mechanisms of inflammation and sites of action of NSAIDs -- Clinical efficacy -- Drug derivatives and formulations -- General safety profile -- Gastro-intestinal toxicity -- Cardiovascular safety -- Renal toxicity -- Hepatic toxicity -- Other adverse reactions -- Global assessment of adverse reactions & human toxicology -- Overall assessment.
Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). Th

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