MHC protocols

種類:

電子ブック

責任表示:

edited by Stephen H. Powis, Robert W. Vaughan

出版情報:

Totowa, N.J. : Humana Press, ©2003

著者名:

• Powis, Stephen H.
• Vaughan, Robert W.

シリーズ名:

Methods in molecular biology ; ; v. 210

ISBN:

9780896035485 [0896035484]    
9781592592913 [1592592910]    
9781280830754 [1280830751]    
9786610830756 [6610830754]    

注記:

Many of the genes found in the human major histocompatibility complex (MHC:HLA region) are subject to extreme polymorphism. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. Many MHC genes also have significant disease association and play a pivotal role in the control of immune response. In MHC Protocols, leading experts detail readily reproducible methods for identifying these polymorphisms in the human MHC. Described in step-by-step detail to ensure robust and successful experimental results, these techniques provide DNA-based protocols for the study of polymorphism in HLA class I and II genes and in non-HLA HMC genes associated with human disease (TAP1, TAP2, C2, C4, and TNF-a). The authors also describe methods for accessing HLA sequence data from electronic databases designed to catalog HLA-region genes and their alleles. Each method is written by an investigator who has used the technique extensively and includes troubleshooting ti
English
Includes bibliographical references and index

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